Talk:Acute tubular necrosis

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There's material at external site Acute Tubular Necrosis that looks useful.

this term may be a some what of a misnomer, detachment comes before death or causes apoposis not necrosis[edit]

Glynne, PA; Evans, TJ (Nov-2001). "Coexpressed nitric oxide synthase and apical beta(1) integrins influence tubule cell adhesion after cytokine-induced injury". Journal of the American Society of Nephrology : JASN. 12 (11): 2370–83. PMID 11675413. Check date values in: |date= (help)CS1 maint: date and year (link)

Glynne, PA (Jun-1999). "Inflammatory cytokines induce apoptotic and necrotic cell shedding from human proximal tubular epithelial cell monolayers". Kidney international. 55 (6): 2573–97. doi:10.1046/j.1523-1755.2002.t01-1-00456.x. PMC 10.1046/j.1523-1755.2002.t01-1-00456.x Check |pmc= value (help). PMID 10354308. Check date values in: |date= (help)CS1 maint: date and year (link)

Racusen, LC. "Epithelial cell shedding in acute renal injury". Clinical and experimental pharmacology & physiology. 25 (3–4): 273–5. PMID 9590582.

Solez, K; Marcussen, N; Slatnik, I; Keown, P; Burdick, JF; Olsen, S (May-1993). "Morphology of ischemic acute renal failure, normal function, and cyclosporine toxicity in cyclosporine-treated renal allograft recipients". Kidney international. 43 (5): 1058–67. PMID 8510383. Check date values in: |date= (help)CS1 maint: date and year (link)

Racusen, LC; Li, YL; Slatnik, I; Solez, K (Apr-1991). "Dissociation of tubular cell detachment and tubular cell death in clinical and experimental "acute tubular necrosis"". Laboratory investigation; a journal of technical methods and pathology. 64 (4): 546–56. PMID 1673163. Check date values in: |date= (help)CS1 maint: date and year (link)


I'm still collecting citations as I can't find keywords that get a good selection but ATN seems to be applied to any condition that causes proxmial tubular epithelium shedding, without regard to actual condition of cells. For example,


Racusen, LC. "Epithelial cell shedding in acute renal injury". Clinical and experimental pharmacology & physiology. 25 (3–4): 273–5. PMID 9590582.


Nerdseeksblonde (talk) 16:35, 22 November 2009 (UTC)

but "shedding" occurs in other processes, for example menstruation, and seems to be regulated. There is some passing indication that bladder cells can shed in response to stress, presumably to fight infection by elimination of cells lkelyh to be infected.

Dalal, E; Harari, O; Aronson, M (Dec-1994). "Moderate stress protects female mice against bacterial infection of the bladder by eliciting uroepithelial shedding". Infection and immunity. 62 (12): 5505–10. PMID 7960132. Check date values in: |date= (help)CS1 maint: date and year (link)

While this may be getting a bit into original rearch, some may be worth including in ATN article as the non-necrotic shedding seems to be still called ATN. Nerdseeksblonde (talk) 16:46, 22 November 2009 (UTC)